A Multicenter Evaluation of Diagnostic Tools to Define Endpoints for Programs to Eliminate Bancroftian Filariasis
Identifieur interne : 004573 ( Main/Exploration ); précédent : 004572; suivant : 004574A Multicenter Evaluation of Diagnostic Tools to Define Endpoints for Programs to Eliminate Bancroftian Filariasis
Auteurs : Katherine Gass [États-Unis] ; Madsen V. E. Beau De Rochars [Haïti] ; Daniel Boakye [Ghana] ; Mark Bradley [Royaume-Uni] ; Peter U. Fischer [États-Unis] ; John Gyapong [Ghana] ; Makoto Itoh [Japon] ; Nese Ituaso-Conway [Tuvalu] ; Hayley Joseph [Australie] ; Dominique Kyelem [États-Unis] ; Sandra J. Laney [États-Unis] ; Anne-Marie Legrand [Polynésie française] ; Tilaka S. Liyanage [Sri Lanka] ; Wayne Melrose [Australie] ; Khalfan Mohammed ; Nils Pilotte [États-Unis] ; Eric A. Ottesen [États-Unis] ; Catherine Plichart [Polynésie française] ; Kapa Ramaiah [Inde] ; Ramakrishna U. Rao [États-Unis] ; Jeffrey Talbot [États-Unis] ; Gary J. Weil [États-Unis] ; Steven A. Williams [États-Unis] ; Kimberly Y. Won [États-Unis] ; Patrick Lammie [États-Unis]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2012.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (sang), Anticorps antihelminthe (urine), Antihelminthiques (usage thérapeutique), Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Humains, Jeune adulte, Mâle, Nourrisson, Nouveau-né, Prévalence, Santé mondiale, Sensibilité et spécificité, Valeur prédictive des tests, Wuchereria bancrofti.
- MESH :
- parasitologie : Filariose lymphatique.
- sang : Anticorps antihelminthe.
- traitement médicamenteux : Filariose lymphatique.
- urine : Anticorps antihelminthe.
- usage thérapeutique : Antihelminthiques.
- épidémiologie : Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Nouveau-né, Prévalence, Santé mondiale, Sensibilité et spécificité, Valeur prédictive des tests, Wuchereria bancrofti.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Anthelmintics (therapeutic use), Antibodies, Helminth (blood), Antibodies, Helminth (urine), Child, Child, Preschool, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (parasitology), Female, Global Health, Humans, Infant, Infant, Newborn, Male, Middle Aged, Predictive Value of Tests, Prevalence, Sensitivity and Specificity, Wuchereria bancrofti, Young Adult.
- MESH :
- chemical , blood : Antibodies, Helminth.
- chemical , therapeutic use : Anthelmintics.
- chemical , urine : Antibodies, Helminth.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- parasitology : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Child, Child, Preschool, Female, Global Health, Humans, Infant, Infant, Newborn, Male, Middle Aged, Predictive Value of Tests, Prevalence, Sensitivity and Specificity, Wuchereria bancrofti, Young Adult.
Abstract
Successful mass drug administration (MDA) campaigns have brought several countries near the point of Lymphatic Filariasis (LF) elimination. A diagnostic tool is needed to determine when the prevalence levels have decreased to a point that MDA campaigns can be discontinued without the threat of recrudescence. A six-country study was conducted assessing the performance of seven diagnostic tests, including tests for microfilariae (blood smear, PCR), parasite antigen (ICT, Og4C3) and antifilarial antibody (Bm14, PanLF, Urine SXP). One community survey and one school survey were performed in each country. A total of 8,513 people from the six countries participated in the study, 6,443 through community surveys and 2,070 through school surveys. Specimens from these participants were used to conduct 49,585 diagnostic tests. Each test was seen to have both positive and negative attributes, but overall, the ICT test was found to be 76% sensitive at detecting microfilaremia and 93% specific at identifying individuals negative for both microfilariae and antifilarial antibody; the Og4C3 test was 87% sensitive and 95% specific. We conclude, however, that the ICT should be the primary tool recommended for decision-making about stopping MDAs. As a point-of-care diagnostic, the ICT is relatively inexpensive, requires no laboratory equipment, has satisfactory sensitivity and specificity and can be processed in 10 minutes—qualities consistent with programmatic use. Og4C3 provides a satisfactory laboratory-based diagnostic alternative.
Url:
DOI: 10.1371/journal.pntd.0001479
PubMed: 22272369
PubMed Central: 3260316
Affiliations:
- Australie, Ghana, Haïti, Inde, Japon, Polynésie française, Royaume-Uni, Sri Lanka, Tuvalu, États-Unis
- Angleterre, Grand Londres, Géorgie (États-Unis), Massachusetts, Missouri (État), Région du Grand Accra
- Accra, Legon (Ghana), Londres, Saint-Louis (Missouri)
- Université du Ghana, École de médecine (Université Washington de Saint-Louis)
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Le document en format XML
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Liyanage</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Anti-Filariasis Campaign, Sri Lanka Ministry of Health and Nutrition, Colombo, Sri Lanka</addr-line></nlm:aff><country xml:lang="fr">Sri Lanka</country><wicri:regionArea>Anti-Filariasis Campaign, Sri Lanka Ministry of Health and Nutrition, Colombo</wicri:regionArea><wicri:noRegion>Colombo</wicri:noRegion></affiliation></author><author><name sortKey="Melrose, Wayne" sort="Melrose, Wayne" uniqKey="Melrose W" first="Wayne" last="Melrose">Wayne Melrose</name><affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Lymphatic Filariasis Support Centre, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Lymphatic Filariasis Support Centre, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Mohammed, Khalfan" sort="Mohammed, Khalfan" uniqKey="Mohammed K" first="Khalfan" last="Mohammed">Khalfan Mohammed</name><affiliation><nlm:aff id="aff13"><addr-line>Neglected Tropical Disease Control Program, Ministry of Health, Zanzibar, United Republic of Tanzania</addr-line></nlm:aff><wicri:noCountry code="subfield">United Republic of Tanzania</wicri:noCountry></affiliation></author><author><name sortKey="Pilotte, Nils" sort="Pilotte, Nils" uniqKey="Pilotte N" first="Nils" last="Pilotte">Nils Pilotte</name><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Department of Biological Sciences, Smith College, Northampton, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, Smith College, Northampton, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ottesen, Eric A" sort="Ottesen, Eric A" uniqKey="Ottesen E" first="Eric A." last="Ottesen">Eric A. Ottesen</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Plichart, Catherine" sort="Plichart, Catherine" uniqKey="Plichart C" first="Catherine" last="Plichart">Catherine Plichart</name><affiliation wicri:level="1"><nlm:aff id="aff11"><addr-line>Institut Louis Malardé, Papeete, Tahiti, French Polynesia</addr-line></nlm:aff><country xml:lang="fr">Polynésie française</country><wicri:regionArea>Institut Louis Malardé, Papeete, Tahiti</wicri:regionArea><wicri:noRegion>Tahiti</wicri:noRegion></affiliation></author><author><name sortKey="Ramaiah, Kapa" sort="Ramaiah, Kapa" uniqKey="Ramaiah K" first="Kapa" last="Ramaiah">Kapa Ramaiah</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Vector Control Research Centre, Indian Council of Medical Research, Pondicherry, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Vector Control Research Centre, Indian Council of Medical Research, Pondicherry</wicri:regionArea><wicri:noRegion>Pondicherry</wicri:noRegion></affiliation></author><author><name sortKey="Rao, Ramakrishna U" sort="Rao, Ramakrishna U" uniqKey="Rao R" first="Ramakrishna U." last="Rao">Ramakrishna U. Rao</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Talbot, Jeffrey" sort="Talbot, Jeffrey" uniqKey="Talbot J" first="Jeffrey" last="Talbot">Jeffrey Talbot</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Weil, Gary J" sort="Weil, Gary J" uniqKey="Weil G" first="Gary J." last="Weil">Gary J. Weil</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Williams, Steven A" sort="Williams, Steven A" uniqKey="Williams S" first="Steven A." last="Williams">Steven A. Williams</name><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Department of Biological Sciences, Smith College, Northampton, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, Smith College, Northampton, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Won, Kimberly Y" sort="Won, Kimberly Y" uniqKey="Won K" first="Kimberly Y." last="Won">Kimberly Y. Won</name><affiliation wicri:level="2"><nlm:aff id="aff15"><addr-line>Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Lammie, Patrick" sort="Lammie, Patrick" uniqKey="Lammie P" first="Patrick" last="Lammie">Patrick Lammie</name><affiliation wicri:level="2"><nlm:aff id="aff15"><addr-line>Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22272369</idno><idno type="pmc">3260316</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260316</idno><idno type="RBID">PMC:3260316</idno><idno type="doi">10.1371/journal.pntd.0001479</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">004396</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004396</idno><idno type="wicri:Area/Pmc/Curation">004395</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004395</idno><idno type="wicri:Area/Pmc/Checkpoint">002C11</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002C11</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002300</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002300</idno><idno type="wicri:Area/PubMed/Curation">002300</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002300</idno><idno type="wicri:Area/PubMed/Checkpoint">002300</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002300</idno><idno type="wicri:Area/Ncbi/Merge">004A05</idno><idno type="wicri:Area/Ncbi/Curation">004A05</idno><idno type="wicri:Area/Ncbi/Checkpoint">004A05</idno><idno type="wicri:doubleKey">1935-2727:2012:Gass K:a:multicenter:evaluation</idno><idno type="wicri:Area/Main/Merge">004597</idno><idno type="wicri:Area/Main/Curation">004573</idno><idno type="wicri:Area/Main/Exploration">004573</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Multicenter Evaluation of Diagnostic Tools to Define Endpoints for Programs to Eliminate Bancroftian Filariasis</title><author><name sortKey="Gass, Katherine" sort="Gass, Katherine" uniqKey="Gass K" first="Katherine" last="Gass">Katherine Gass</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Beau De Rochars, Madsen V E" sort="Beau De Rochars, Madsen V E" uniqKey="Beau De Rochars M" first="Madsen V. E." last="Beau De Rochars">Madsen V. E. Beau De Rochars</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Hopital Ste. Croix, Leogane, Haiti</addr-line></nlm:aff><country xml:lang="fr">Haïti</country><wicri:regionArea>Hopital Ste. Croix, Leogane</wicri:regionArea><wicri:noRegion>Leogane</wicri:noRegion></affiliation></author><author><name sortKey="Boakye, Daniel" sort="Boakye, Daniel" uniqKey="Boakye D" first="Daniel" last="Boakye">Daniel Boakye</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Noguchi Memorial Institute for Medical Research, University of Ghana, Legon-Accra</wicri:regionArea><orgName type="university">Université du Ghana</orgName><placeName><settlement type="city">Accra</settlement><settlement type="town">Legon (Ghana)</settlement><region type="region">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Bradley, Mark" sort="Bradley, Mark" uniqKey="Bradley M" first="Mark" last="Bradley">Mark Bradley</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Global Community Partnerships, GlaxoSmithKline, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Global Community Partnerships, GlaxoSmithKline, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Fischer, Peter U" sort="Fischer, Peter U" uniqKey="Fischer P" first="Peter U." last="Fischer">Peter U. Fischer</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Gyapong, John" sort="Gyapong, John" uniqKey="Gyapong J" first="John" last="Gyapong">John Gyapong</name><affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Research and Development Division, Ghana Health Service, Accra, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Research and Development Division, Ghana Health Service, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Itoh, Makoto" sort="Itoh, Makoto" uniqKey="Itoh M" first="Makoto" last="Itoh">Makoto Itoh</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Parasitology, Aichi Medical University School of Medicine, Nagakute, Aichi-ken, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Parasitology, Aichi Medical University School of Medicine, Nagakute, Aichi-ken</wicri:regionArea><wicri:noRegion>Aichi-ken</wicri:noRegion></affiliation></author><author><name sortKey="Ituaso Conway, Nese" sort="Ituaso Conway, Nese" uniqKey="Ituaso Conway N" first="Nese" last="Ituaso-Conway">Nese Ituaso-Conway</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>National Program for Elimination of Lymphatic Filariasis, Ministry of Health, Funafuti, Tuvalu</addr-line></nlm:aff><country xml:lang="fr">Tuvalu</country><wicri:regionArea>National Program for Elimination of Lymphatic Filariasis, Ministry of Health, Funafuti</wicri:regionArea><wicri:noRegion>Funafuti</wicri:noRegion></affiliation></author><author><name sortKey="Joseph, Hayley" sort="Joseph, Hayley" uniqKey="Joseph H" first="Hayley" last="Joseph">Hayley Joseph</name><affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Lymphatic Filariasis Support Centre, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Lymphatic Filariasis Support Centre, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Kyelem, Dominique" sort="Kyelem, Dominique" uniqKey="Kyelem D" first="Dominique" last="Kyelem">Dominique Kyelem</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Laney, Sandra J" sort="Laney, Sandra J" uniqKey="Laney S" first="Sandra J." last="Laney">Sandra J. Laney</name><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Department of Biological Sciences, Smith College, Northampton, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, Smith College, Northampton, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Legrand, Anne Marie" sort="Legrand, Anne Marie" uniqKey="Legrand A" first="Anne-Marie" last="Legrand">Anne-Marie Legrand</name><affiliation wicri:level="1"><nlm:aff id="aff11"><addr-line>Institut Louis Malardé, Papeete, Tahiti, French Polynesia</addr-line></nlm:aff><country xml:lang="fr">Polynésie française</country><wicri:regionArea>Institut Louis Malardé, Papeete, Tahiti</wicri:regionArea><wicri:noRegion>Tahiti</wicri:noRegion></affiliation></author><author><name sortKey="Liyanage, Tilaka S" sort="Liyanage, Tilaka S" uniqKey="Liyanage T" first="Tilaka S." last="Liyanage">Tilaka S. Liyanage</name><affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Anti-Filariasis Campaign, Sri Lanka Ministry of Health and Nutrition, Colombo, Sri Lanka</addr-line></nlm:aff><country xml:lang="fr">Sri Lanka</country><wicri:regionArea>Anti-Filariasis Campaign, Sri Lanka Ministry of Health and Nutrition, Colombo</wicri:regionArea><wicri:noRegion>Colombo</wicri:noRegion></affiliation></author><author><name sortKey="Melrose, Wayne" sort="Melrose, Wayne" uniqKey="Melrose W" first="Wayne" last="Melrose">Wayne Melrose</name><affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Lymphatic Filariasis Support Centre, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Lymphatic Filariasis Support Centre, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Mohammed, Khalfan" sort="Mohammed, Khalfan" uniqKey="Mohammed K" first="Khalfan" last="Mohammed">Khalfan Mohammed</name><affiliation><nlm:aff id="aff13"><addr-line>Neglected Tropical Disease Control Program, Ministry of Health, Zanzibar, United Republic of Tanzania</addr-line></nlm:aff><wicri:noCountry code="subfield">United Republic of Tanzania</wicri:noCountry></affiliation></author><author><name sortKey="Pilotte, Nils" sort="Pilotte, Nils" uniqKey="Pilotte N" first="Nils" last="Pilotte">Nils Pilotte</name><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Department of Biological Sciences, Smith College, Northampton, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, Smith College, Northampton, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ottesen, Eric A" sort="Ottesen, Eric A" uniqKey="Ottesen E" first="Eric A." last="Ottesen">Eric A. Ottesen</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Plichart, Catherine" sort="Plichart, Catherine" uniqKey="Plichart C" first="Catherine" last="Plichart">Catherine Plichart</name><affiliation wicri:level="1"><nlm:aff id="aff11"><addr-line>Institut Louis Malardé, Papeete, Tahiti, French Polynesia</addr-line></nlm:aff><country xml:lang="fr">Polynésie française</country><wicri:regionArea>Institut Louis Malardé, Papeete, Tahiti</wicri:regionArea><wicri:noRegion>Tahiti</wicri:noRegion></affiliation></author><author><name sortKey="Ramaiah, Kapa" sort="Ramaiah, Kapa" uniqKey="Ramaiah K" first="Kapa" last="Ramaiah">Kapa Ramaiah</name><affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Vector Control Research Centre, Indian Council of Medical Research, Pondicherry, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Vector Control Research Centre, Indian Council of Medical Research, Pondicherry</wicri:regionArea><wicri:noRegion>Pondicherry</wicri:noRegion></affiliation></author><author><name sortKey="Rao, Ramakrishna U" sort="Rao, Ramakrishna U" uniqKey="Rao R" first="Ramakrishna U." last="Rao">Ramakrishna U. Rao</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Talbot, Jeffrey" sort="Talbot, Jeffrey" uniqKey="Talbot J" first="Jeffrey" last="Talbot">Jeffrey Talbot</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lymphatic Filariasis Support Center, The Task Force for Global Health, Decatur, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Weil, Gary J" sort="Weil, Gary J" uniqKey="Weil G" first="Gary J." last="Weil">Gary J. Weil</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Williams, Steven A" sort="Williams, Steven A" uniqKey="Williams S" first="Steven A." last="Williams">Steven A. Williams</name><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Department of Biological Sciences, Smith College, Northampton, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, Smith College, Northampton, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Won, Kimberly Y" sort="Won, Kimberly Y" uniqKey="Won K" first="Kimberly Y." last="Won">Kimberly Y. Won</name><affiliation wicri:level="2"><nlm:aff id="aff15"><addr-line>Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Lammie, Patrick" sort="Lammie, Patrick" uniqKey="Lammie P" first="Patrick" last="Lammie">Patrick Lammie</name><affiliation wicri:level="2"><nlm:aff id="aff15"><addr-line>Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Neglected Tropical Diseases</title><idno type="ISSN">1935-2727</idno><idno type="eISSN">1935-2735</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Anthelmintics (therapeutic use)</term><term>Antibodies, Helminth (blood)</term><term>Antibodies, Helminth (urine)</term><term>Child</term><term>Child, Preschool</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Global Health</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prevalence</term><term>Sensitivity and Specificity</term><term>Wuchereria bancrofti</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Anticorps antihelminthe (sang)</term><term>Anticorps antihelminthe (urine)</term><term>Antihelminthiques (usage thérapeutique)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Prévalence</term><term>Santé mondiale</term><term>Sensibilité et spécificité</term><term>Valeur prédictive des tests</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anthelmintics</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Antibodies, Helminth</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Anticorps antihelminthe</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antihelminthiques</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Global Health</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prevalence</term><term>Sensitivity and Specificity</term><term>Wuchereria bancrofti</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Prévalence</term><term>Santé mondiale</term><term>Sensibilité et spécificité</term><term>Valeur prédictive des tests</term><term>Wuchereria bancrofti</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Successful mass drug administration (MDA) campaigns have brought several countries near the point of Lymphatic Filariasis (LF) elimination. A diagnostic tool is needed to determine when the prevalence levels have decreased to a point that MDA campaigns can be discontinued without the threat of recrudescence. A six-country study was conducted assessing the performance of seven diagnostic tests, including tests for microfilariae (blood smear, PCR), parasite antigen (ICT, Og4C3) and antifilarial antibody (Bm14, PanLF, Urine SXP). One community survey and one school survey were performed in each country. A total of 8,513 people from the six countries participated in the study, 6,443 through community surveys and 2,070 through school surveys. Specimens from these participants were used to conduct 49,585 diagnostic tests. Each test was seen to have both positive and negative attributes, but overall, the ICT test was found to be 76% sensitive at detecting microfilaremia and 93% specific at identifying individuals negative for both microfilariae and antifilarial antibody; the Og4C3 test was 87% sensitive and 95% specific. We conclude, however, that the ICT should be the primary tool recommended for decision-making about stopping MDAs. As a point-of-care diagnostic, the ICT is relatively inexpensive, requires no laboratory equipment, has satisfactory sensitivity and specificity and can be processed in 10 minutes—qualities consistent with programmatic use. Og4C3 provides a satisfactory laboratory-based diagnostic alternative.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author><author><name sortKey="Hooper, Pj" uniqKey="Hooper P">PJ Hooper</name></author><author><name sortKey="Bradley, M" uniqKey="Bradley M">M Bradley</name></author><author><name sortKey="Biswas, G" uniqKey="Biswas G">G Biswas</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ramzy, Rm" uniqKey="Ramzy R">RM Ramzy</name></author><author><name sortKey="El Setouhy, M" uniqKey="El Setouhy M">M El Setouhy</name></author><author><name sortKey="Helmy, H" uniqKey="Helmy H">H Helmy</name></author><author><name sortKey="Ahmed, Es" uniqKey="Ahmed E">ES Ahmed</name></author><author><name sortKey="Abd Elaziz, Km" uniqKey="Abd Elaziz K">KM Abd 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S">SL Hoti</name></author><author><name sortKey="Elango, A" uniqKey="Elango A">A Elango</name></author><author><name sortKey="Radjame, K" uniqKey="Radjame K">K Radjame</name></author><author><name sortKey="Yuvaraj, J" uniqKey="Yuvaraj J">J Yuvaraj</name></author><author><name sortKey="Pani, Sp" uniqKey="Pani S">SP Pani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Itoh, M" uniqKey="Itoh M">M Itoh</name></author><author><name sortKey="Gunawardena, Nk" uniqKey="Gunawardena N">NK Gunawardena</name></author><author><name sortKey="Qiu, Xg" uniqKey="Qiu X">XG Qiu</name></author><author><name sortKey="Weerasooriya, Mv" uniqKey="Weerasooriya M">MV Weerasooriya</name></author><author><name sortKey="Kimura, E" uniqKey="Kimura E">E Kimura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Terhell, Aj" uniqKey="Terhell A">AJ Terhell</name></author><author><name sortKey="Haarbrink, M" uniqKey="Haarbrink M">M Haarbrink</name></author><author><name sortKey="Abadi, K" uniqKey="Abadi K">K Abadi</name></author><author><name sortKey="Bronneberg, Dc" uniqKey="Bronneberg D">DC Bronneberg</name></author><author><name sortKey="Tieleman, Mc" uniqKey="Tieleman M">MC Tieleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joseph, Hm" uniqKey="Joseph H">HM Joseph</name></author><author><name sortKey="Melrose, W" uniqKey="Melrose W">W Melrose</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weil, Gj" uniqKey="Weil G">GJ Weil</name></author><author><name sortKey="Curtis, Kc" uniqKey="Curtis K">KC Curtis</name></author><author><name sortKey="Fischer, Pu" uniqKey="Fischer P">PU Fischer</name></author><author><name sortKey="Won, Ky" uniqKey="Won K">KY Won</name></author><author><name sortKey="Lammie, Pj" uniqKey="Lammie P">PJ Lammie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chanteau, S" uniqKey="Chanteau S">S Chanteau</name></author><author><name sortKey="Moulia Pelat, Jp" uniqKey="Moulia Pelat J">JP Moulia-Pelat</name></author><author><name sortKey="Glaziou, P" uniqKey="Glaziou P">P Glaziou</name></author><author><name sortKey="Nguyen, Nl" uniqKey="Nguyen N">NL Nguyen</name></author><author><name sortKey="Luquiaud, P" uniqKey="Luquiaud P">P Luquiaud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rocha, A" uniqKey="Rocha A">A Rocha</name></author><author><name sortKey="Braga, C" uniqKey="Braga C">C Braga</name></author><author><name sortKey="Belem, M" uniqKey="Belem M">M Belem</name></author><author><name sortKey="Carrera, A" uniqKey="Carrera A">A Carrera</name></author><author><name sortKey="Aguiar Santos, A" uniqKey="Aguiar Santos A">A Aguiar-Santos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wattal, S" uniqKey="Wattal S">S Wattal</name></author><author><name sortKey="Dhariwal, Ac" uniqKey="Dhariwal A">AC Dhariwal</name></author><author><name sortKey="Ralhan, Pk" uniqKey="Ralhan P">PK Ralhan</name></author><author><name sortKey="Tripathi, Vc" uniqKey="Tripathi V">VC Tripathi</name></author><author><name sortKey="Regu, K" uniqKey="Regu K">K Regu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Ghana</li><li>Haïti</li><li>Inde</li><li>Japon</li><li>Polynésie française</li><li>Royaume-Uni</li><li>Sri Lanka</li><li>Tuvalu</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Géorgie (États-Unis)</li><li>Massachusetts</li><li>Missouri (État)</li><li>Région du Grand Accra</li></region><settlement><li>Accra</li><li>Legon (Ghana)</li><li>Londres</li><li>Saint-Louis (Missouri)</li></settlement><orgName><li>Université du Ghana</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><noCountry><name sortKey="Mohammed, Khalfan" sort="Mohammed, Khalfan" uniqKey="Mohammed K" first="Khalfan" last="Mohammed">Khalfan Mohammed</name></noCountry><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Gass, Katherine" sort="Gass, Katherine" uniqKey="Gass K" first="Katherine" last="Gass">Katherine Gass</name></region><name sortKey="Fischer, Peter U" sort="Fischer, Peter U" uniqKey="Fischer P" first="Peter U." last="Fischer">Peter U. Fischer</name><name sortKey="Kyelem, Dominique" sort="Kyelem, Dominique" uniqKey="Kyelem D" first="Dominique" last="Kyelem">Dominique Kyelem</name><name sortKey="Lammie, Patrick" sort="Lammie, Patrick" uniqKey="Lammie P" first="Patrick" last="Lammie">Patrick Lammie</name><name sortKey="Laney, Sandra J" sort="Laney, Sandra J" uniqKey="Laney S" first="Sandra J." last="Laney">Sandra J. Laney</name><name sortKey="Ottesen, Eric A" sort="Ottesen, Eric A" uniqKey="Ottesen E" first="Eric A." last="Ottesen">Eric A. Ottesen</name><name sortKey="Pilotte, Nils" sort="Pilotte, Nils" uniqKey="Pilotte N" first="Nils" last="Pilotte">Nils Pilotte</name><name sortKey="Rao, Ramakrishna U" sort="Rao, Ramakrishna U" uniqKey="Rao R" first="Ramakrishna U." last="Rao">Ramakrishna U. Rao</name><name sortKey="Talbot, Jeffrey" sort="Talbot, Jeffrey" uniqKey="Talbot J" first="Jeffrey" last="Talbot">Jeffrey Talbot</name><name sortKey="Weil, Gary J" sort="Weil, Gary J" uniqKey="Weil G" first="Gary J." last="Weil">Gary J. Weil</name><name sortKey="Williams, Steven A" sort="Williams, Steven A" uniqKey="Williams S" first="Steven A." last="Williams">Steven A. Williams</name><name sortKey="Won, Kimberly Y" sort="Won, Kimberly Y" uniqKey="Won K" first="Kimberly Y." last="Won">Kimberly Y. Won</name></country><country name="Haïti"><noRegion><name sortKey="Beau De Rochars, Madsen V E" sort="Beau De Rochars, Madsen V E" uniqKey="Beau De Rochars M" first="Madsen V. E." last="Beau De Rochars">Madsen V. E. Beau De Rochars</name></noRegion></country><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Boakye, Daniel" sort="Boakye, Daniel" uniqKey="Boakye D" first="Daniel" last="Boakye">Daniel Boakye</name></region><name sortKey="Gyapong, John" sort="Gyapong, John" uniqKey="Gyapong J" first="John" last="Gyapong">John Gyapong</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bradley, Mark" sort="Bradley, Mark" uniqKey="Bradley M" first="Mark" last="Bradley">Mark Bradley</name></region></country><country name="Japon"><noRegion><name sortKey="Itoh, Makoto" sort="Itoh, Makoto" uniqKey="Itoh M" first="Makoto" last="Itoh">Makoto Itoh</name></noRegion></country><country name="Tuvalu"><noRegion><name sortKey="Ituaso Conway, Nese" sort="Ituaso Conway, Nese" uniqKey="Ituaso Conway N" first="Nese" last="Ituaso-Conway">Nese Ituaso-Conway</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Joseph, Hayley" sort="Joseph, Hayley" uniqKey="Joseph H" first="Hayley" last="Joseph">Hayley Joseph</name></noRegion><name sortKey="Melrose, Wayne" sort="Melrose, Wayne" uniqKey="Melrose W" first="Wayne" last="Melrose">Wayne Melrose</name></country><country name="Polynésie française"><noRegion><name sortKey="Legrand, Anne Marie" sort="Legrand, Anne Marie" uniqKey="Legrand A" first="Anne-Marie" last="Legrand">Anne-Marie Legrand</name></noRegion><name sortKey="Plichart, Catherine" sort="Plichart, Catherine" uniqKey="Plichart C" first="Catherine" last="Plichart">Catherine Plichart</name></country><country name="Sri Lanka"><noRegion><name sortKey="Liyanage, Tilaka S" sort="Liyanage, Tilaka S" uniqKey="Liyanage T" first="Tilaka S." last="Liyanage">Tilaka S. Liyanage</name></noRegion></country><country name="Inde"><noRegion><name sortKey="Ramaiah, Kapa" sort="Ramaiah, Kapa" uniqKey="Ramaiah K" first="Kapa" last="Ramaiah">Kapa Ramaiah</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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